Thanks Roman, but the server this site is running on has 100+ GB of disk space left, and almost 4GB of free RAM, so it doesn't seem like resources are an issue.
Brenden, thanks, I'll try expanding the AppPool user's permissions to see if that helps. I've already had to add permissions for the /Export and the /App_Data/Persistent directories. I'll try going up a level and adding permissions.
thanks,
Marcel