Kentico right now does not support ASP.NET 4.6, so proceed at your own risk. I got it to 'work' on my system but page load was taking a ton of time. I ended up having to revert back to 2013 and get rid of 4.6 off my system all together.
As of now Kentico has said they will support 2015 and 4.6 with version 9